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Goldberg bipolar test pdf4/3/2023 ![]() ![]() ![]() Yet, when one considers the numerous other clinical, demographic and psychosocial factors that impinge on how any given psychiatric disorder presents, it is not hard to reframe Sir William Osler’s aphorism about “what sort of patient has a disease” as a reckoning of clinical diversity (or what geneticists might call phenotypic heterogeneity). Clinicians sometimes merely equate “personalized medicine” with biomarkers (such as pharmacogenetics), dismissing most other aspects of pharmacotherapy decision-making as largely a trial-and-error process. Imagine devising a pharmacotherapy regimen for each and every patient you see with the same kind of individualized precision and artisanal craftsmanship that an expert tailor uses to create a bespoke suit of clothing. “It is much more important to know what sort of a patient has a disease ![]()
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